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apalutamide will minimize the level or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which might be CYP3A4 substrates may lead to decreased exposure to those medications.If jaundice develops in any fema